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Updated: Jun 2, 2026
A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
Published on: November 8, 2019
[Treatment of ischemia-reperfusion injury of flap]
Wenqi Gu1, Wei Zhang, Yimin Chai
1Department of Orthopedics, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China.
Objective:
To review the treatment methods and techniques of ischemia-reperfusion injury of flap.
Methods:
Recent basic research literature concerning ischemia-reperfusion injury of flap was reviewed and analyzed in terms of treatment techniques.
Results:
Ischemia-reperfusion injury is one of the leading causes of flap necrosis postoperatively. Interventions against any link of the ischemia-reperfusion injury progress could effectively reduce the damage and improve the survival rate of flaps.
Conclusion:
Including production of reactive oxygen species, neutrophil infiltration etc are thought to be the main mechanisms of ischemia-reperfusion injury. Treatment including medicine administration and physical intervention against any specific link of ischemia-reperfusion injury can interfere or block the whole progress, which reduce the damage of ischemia-reperfusion injury and improve the survival rate of animal flap models eventually.
