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Depression: Overview01:18

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Jun 2, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

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Published on: April 23, 2014

Does the Veterans Affairs depression performance measure predict quality care?

Brian Shiner1, Bradley V Watts, Marcy K Traum

  • 1Department of Veterans Affairs (VA) Medical Center, White River Junction, Vermont, USA. brian.r.shiner@dartmouth.edu

Joint Commission Journal on Quality and Patient Safety
|April 20, 2011
PubMed
Summary

High-performing Department of Veterans Affairs (VA) sites adhered to depression care processes more than low-performing sites. This study validated a model for assessing depression care quality in the VA healthcare system.

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Area of Science:

  • Health Services Research
  • Quality Improvement in Healthcare
  • Mental Health Services Evaluation

Background:

  • The Department of Veterans Affairs (VA) implemented a depression care quality measure in 2000.
  • This measure was removed in FY2009 due to lack of empirical validation.
  • A need existed to compare the VA measure with a validated model for assessing depression care.

Purpose of the Study:

  • To compare the VA depression performance measure with an empirically validated model for assessing depression care quality.
  • To evaluate adherence to evidence-based depression care processes.

Main Methods:

  • Selected VA medical centers (VAMCs) in the top or bottom quartile for the VA depression measure in FY2008.
  • Conducted telephone interviews with clinical directors using an adapted 3-Component Model (3CM) fidelity scale.
  • Assessed adherence to key domains of evidence-based depression care.

Main Results:

  • Significant differences in patient adherence to the VA depression measure between high- and low-performing groups (47.5% vs. 14.7%).
  • The 3CM fidelity scale detected significant differences in depression care processes between high- and low-performing sites (82.3 vs. 71.4).

Conclusions:

  • High-performing sites on the VA depression measure demonstrated better adherence to important depression care processes.
  • The 3CM fidelity measure effectively differentiated between high- and low-performing sites in depression care quality.