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Updated: Jun 2, 2026
08:05
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Application of proteomics in asthma research
1Genome Research Center for Allergy and Respiratory Disease, Soonchunhyang University Hospital, Bucheon, South Korea.
Expert Review of Proteomics
|April 20, 2011
Summary
Proteomics offers new ways to find asthma biomarkers by analyzing protein changes in various stages of the disease. This
Area of Science:
- * Pulmonary Medicine and Molecular Biology
- * Genomics and Proteomics in Disease Research
Background:
- * Bronchial asthma is a complex allergic airway inflammatory disease characterized by reversible airway obstruction and hyper-responsiveness.
- * Asthma pathophysiology involves intricate genetic and environmental interactions affecting numerous molecular and biochemical pathways.
- * Identifying underlying disease mechanisms has been challenging due to asthma's complex phenotype and genetic heterogeneity.
Purpose of the Study:
- * To review the application of proteomic technology in identifying asthma marker proteins.
- * To explore how 'omics biology' can aid in early disease detection and novel drug target identification.
- * To provide insights into the molecular mechanisms of asthma through protein expression analysis.
Main Methods:
- * Review of studies utilizing proteomic technologies to identify protein biomarkers.
- * Analysis of protein expression changes from cell models to clinical samples in asthma.
- * Integration of genomic and proteomic data for disease association studies.
Main Results:
- * Proteomic approaches can identify specific protein alterations associated with different asthma stages.
- * 'Omics biology' facilitates the discovery of potential molecular targets for asthma therapies.
- * Analysis of protein changes offers deeper understanding of asthma's complex molecular underpinnings.
Conclusions:
- * Proteomic technology is a valuable tool for discovering novel asthma biomarkers and pathological mediators.
- * Identifying protein changes can elucidate complex molecular mechanisms in asthma.
- * This approach holds promise for advancing early diagnosis, prevention, and treatment strategies for asthma.
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