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Related Concept Videos

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
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Synthesis and Regulation of Thyroid Hormones

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Steady State Concentration

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The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
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A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function
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Published on: October 6, 2023

Stability of thyroid hormones during continuous infusion.

Sergio G Golombek1, Gad Alpan, Michael Frey

  • 1Division of Newborn Medicine, Department of Pediatrics, The Regional Neonatal Center, Maria Fareri Children's Hospital at Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA. sergio_golombek@nymc.edu

Journal of Perinatal Medicine
|April 20, 2011
PubMed
Summary

To ensure accurate intravenous thyroid hormone dosing, add albumin to IV fluids. Albumin prevents thyroid hormones like thyroxine (T4) and triiodothyronine (T3) from adhering to plastic tubing, maintaining drug stability.

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Area of Science:

  • Endocrinology
  • Pharmaceutical Sciences
  • Clinical Pharmacy

Background:

  • Thyroid hormones are crucial for metabolic regulation.
  • Continuous intravenous infusion is a method for administering thyroid hormones.
  • Plastic intravenous tubing can potentially adsorb drug solutions, affecting dosage accuracy.

Purpose of the Study:

  • To evaluate the stability and recovery of thyroid hormones (T4 and T3) during continuous infusion in polypropylene tubing.
  • To determine optimal preparation methods to prevent drug loss in intravenous administration.

Main Methods:

  • Thyroid hormones were diluted using aseptic technique and stored at 2-8°C.
  • Stability and percent recovery were tested within 24 hours in polypropylene tubing.
  • Experiments involved duplicate preparations and triplicate readings, with varying solutions including 5% dextrose water (D5W) and albumin.

Main Results:

  • Thyroxine (T4) in 5% dextrose water with 1 mg/mL albumin demonstrated stability and accuracy.
  • Other preparation methods resulted in up to 40% drug loss due to adherence to plastic.
  • Triiodothyronine (T3) recovery was 107±2% when 1 mg/mL albumin was included.

Conclusions:

  • Adding 1 mg/mL albumin to the infusate is essential for maintaining stable and accurate intravenous thyroid hormone dosing.
  • Albumin prevents thyroid hormone adsorption to plastic intravenous tubing, ensuring therapeutic efficacy.