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Related Experiment Video

Updated: Jun 2, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
08:43

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

Gingival tissue transcriptomes in experimental gingivitis.

Daniel Jönsson1, Per Ramberg, Ryan T Demmer

  • 1Division of Periodontics, Section of Oral and Diagnostic Sciences, College of Dental Medicine, Columbia University, New York, NY 10032, USA.

Journal of Clinical Periodontology
|April 20, 2011
PubMed
Summary
This summary is machine-generated.

This study tracked gene expression changes in gingival tissue during experimental gingivitis. Key pathways like leukocyte transmigration were significantly altered during both disease induction and resolution.

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Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

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Last Updated: Jun 2, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
08:43

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

Area of Science:

  • Oral biology
  • Inflammation research
  • Transcriptomics

Background:

  • Experimental gingivitis is a reversible inflammatory condition.
  • Understanding the dynamic gene expression during gingivitis is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate sequential gene expression in gingival tissue during the induction and resolution phases of experimental gingivitis.
  • To identify key biological pathways involved in the inflammatory response and its reversal.

Main Methods:

  • Twenty healthy volunteers underwent a 3-week experimental gingivitis protocol followed by plaque control.
  • Gingival tissue samples were collected at multiple time points during induction and resolution phases.
  • Gene expression profiling was performed using Affymetrix microarrays, followed by gene ontology analysis.

Main Results:

  • Gingival inflammation (gingival index) peaked at 3 weeks and partially resolved after 2 weeks of plaque control.
  • Differential gene regulation was most pronounced during the third week of induction and the initial days of resolution.
  • Top differentially regulated pathways included leukocyte transmigration, cell adhesion, and antigen processing/presentation.

Conclusions:

  • Transcriptomic analysis provides a dynamic view of tissue responses in experimental gingivitis.
  • This study enhances understanding of the pathobiology of reversible gingival inflammation.
  • The findings highlight key molecular events during gingivitis induction and resolution.