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Related Concept Videos

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...

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Related Experiment Video

Updated: Jun 2, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

TLR based therapeutics.

Aisling Dunne1, Neil A Marshall, Kingston H G Mills

  • 1School of Biochemistry and Immunology, and Immunology Research Centre, Trinity College Dublin, Ireland.

Current Opinion in Pharmacology
|April 20, 2011
PubMed
Summary
This summary is machine-generated.

Toll-like receptors (TLRs) are key to immune responses. TLR agonists aid vaccines and cancer therapies but can worsen inflammatory diseases, prompting research into TLR inhibitors for treating such conditions.

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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
07:56

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

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Last Updated: Jun 2, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
07:56

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

Area of Science:

  • Immunology
  • Infectious Disease
  • Oncology

Background:

  • Toll-like receptors (TLRs) are critical components of the innate immune system, mediating responses to pathogens.
  • TLR activation by agonists enhances antigen-presenting cell maturation, bridging innate and adaptive immunity.

Purpose of the Study:

  • To explore the dual role of TLR agonists in immunity and inflammation.
  • To investigate the therapeutic potential of targeting TLRs for various diseases.

Main Methods:

  • Review of TLR function in immune responses.
  • Analysis of TLR agonist applications in vaccine adjuvants and cancer therapy.
  • Examination of TLRs' role in inflammatory and autoimmune diseases.

Main Results:

  • TLR agonists are effective vaccine adjuvants and anti-cancer therapeutics.
  • TLR agonists also drive inflammatory cytokine production, contributing to autoimmune diseases.
  • Antibodies and inhibitors targeting TLRs show promise for inflammatory disorders.

Conclusions:

  • TLRs represent a significant target for therapeutic intervention.
  • Targeting TLRs offers potential for both enhancing immunity and mitigating inflammation.