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Involvement of lipoproteins in suppression of interleukin 2-dependent cell proliferation by sera from aged humans
Y Ohtsuka1, K Kobayashi, T Hirano
1First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Abstract:
Sera from the elderly, but not young, inhibited markedly interleukin 2 (IL-2)-dependent proliferation of cloned T cells. Sera of aged humans contained high levels of triglyceride, cholesterol, very low density lipoproteins (VLDL) and low density lipoproteins (LDL). VLDL and LDL inhibited the proliferation in a dose-related manner. The inhibition correlated with levels of serum VLDL and LDL. These results suggest that lipoproteins may act as a regulator of IL-2-dependent proliferation and that disturbance of lipid and lipoprotein metabolism may be partially responsible for diminished immune responses in the elderly.