Synthesis, characterization and biological activities of substituted cinnoline culphonamides
1Indian Veterinary Research Institute, Surgery Division, India. vikasvicky17@rediffmail.com
Background:
The Cinnoline moiety and Sulphonamide moiety both have good antimicrobial properties.
Methods:
In the present study both the moieties were condensed to synthesize substituted cinnoline sulphonamide derivatives using intramolecular cyclization followed by diazotization in order to get synergistic activity.
Results:
These derivatives particularly halogen substituted cinnoline derivatives showed potent antimicrobial activity.
Conclusion:
Further investigations are required to find out possible mechanism of action.
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