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[Association between left ventricular wall motion abnormalities and ventricular arrhythmia in the indeterminate form

Márcio Lins Barros1, Antônio Ribeiro, Maria do Carmo Nunes

  • 1Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG. marciovlbarros@uol.com.br

Revista Da Sociedade Brasileira De Medicina Tropical
|April 20, 2011
PubMed

Insights

Chagas

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • Chagas' disease poses a significant risk of severe cardiac damage.
  • Early identification of cardiac abnormalities in the indeterminate form (IF) is crucial for risk stratification.
  • The indeterminate form of Chagas' disease can present subclinical cardiac involvement.

Purpose of the Study:

  • To investigate functional and electrical cardiac disturbances in IF Chagas' disease patients with wall motion abnormalities.
  • To compare cardiac function and electrical activity between IF patients with and without echocardiographic abnormalities.

Main Methods:

  • Studied 38 patients with the indeterminate form of Chagas' disease.
  • Included 26 patients with normal echocardiograms and 12 with segmental wall motion abnormalities.
  • Utilized complete echocardiogram, Doppler, tissue Doppler imaging (TDI), and 24-hour Holter monitoring.

Main Results:

  • Significant differences observed in ejection fraction (p ≤ 0.001) and left ventricular systolic dimension (p = 0.029).
  • Isovolumic contraction time (TDI) in basal left ventricular segments was significantly altered (p < 0.05).
  • Increased presence of isolated (p = 0.0005) and paired ventricular extrasystoles (p = 0.003) detected by Holter monitoring.

Conclusions:

  • The indeterminate form of Chagas' disease can manifest with cardiac wall motion abnormalities.
  • These abnormalities are associated with demonstrable functional and electrical cardiac damage.
  • Findings highlight the importance of comprehensive cardiac evaluation in IF Chagas' disease patients.
Abstract

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