[Experimental study of the effect of acetylsalicylic acid on the ultrastructure and function of thrombocytes]

Data are presented on yak platelet ultrastructure (in comparison with human platelets), and on acetylsalicylic acid influence on the platelet ultrastructure and function. The following species features of this animals are associated with their adaptation to high-altitude hypoxia: organization of alpha-granules, mitochondria, the contractile system (microtubes, F-actin), ovoid form of platelets. Acetylsalicylic acid influences the yak platelet plasma membrane inducing fragmentation, which is attended by a rise in the total number of platelets, by the appearance of a great number of microforms, and by the reduction of functional activity. The above changes remained up to 11 days from the beginning of the drug action.