Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Automated Microbial Diagnostics

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Tuberculosis

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

Rapid Identification of Pathogens

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Changing the game for multidrug-resistant tuberculosis.

Lancet (London, England)·2016

Same author

India is failing the mentally ill as abuses continue.

Lancet (London, England)·2010

Same author

India failing children orphaned by AIDS.

Lancet (London, England)·2010

Same author

Can public-private partnerships improve health in India?

Lancet (London, England)·2008

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

Tuberculosis diagnostics: innovating to make an impact.

Bharathi Ghanashyam¹

¹The Akshaya Patra Foundation, Bangalore, India. bharathiksg@gmail.com

Expert Review of Anti-Infective Therapy

|April 21, 2011

Summary

This symposium highlighted advances in tuberculosis (TB) diagnostics, including new molecular assays and WHO-endorsed tools. It also addressed challenges like test misuse and quality assurance for effective TB diagnosis implementation.

Area of Science:

Tuberculosis Diagnostics Research
Medical Innovation
Global Health

Background:

The International Symposium on TB Diagnostics convened experts to discuss advancements and challenges in tuberculosis diagnostics.
Key sponsors included the Bill & Melinda Gates Foundation, Foundation for Innovative New Diagnostics, and AERAS Global TB Vaccine Foundation.

Framework:

Exploration of recent scientific advances in TB diagnostics.
Review of progress in expanding the TB diagnostics pipeline with validated tools.
Discussion on the development of molecular assays for point-of-care use.

Implementation:

Addressing the widespread abuse of inappropriate diagnostic tests.
Highlighting the critical need for quality assurance in laboratories.

More Related Videos

Amplicon Sequencing using the Long-Read Sequencing Technologies

Amplicon Sequencing using the Long-Read Sequencing Technologies

Published on: August 29, 2025

Related Experiment Videos

Last Updated: Jun 2, 2026

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

Amplicon Sequencing using the Long-Read Sequencing Technologies

Amplicon Sequencing using the Long-Read Sequencing Technologies

Published on: August 29, 2025

Examining regulatory challenges for the rollout of new diagnostic tools.

Implications:

Identifying opportunities for emerging economies, particularly India, to contribute to TB diagnostics.
Fostering discussion on India's potential to lead global TB innovations.
Emphasizing the need for strategic focus to overcome implementation barriers for effective TB diagnosis.