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Adjuvant radiation treatment after prostatectomy. Where do we stand?
Mohamed A Elshaikh1, Dina R Ibrahim, Hans Stricker
1Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202, USA.
The Canadian Journal of Urology
|April 21, 2011
Summary
Adjuvant radiation treatment (ART) after prostatectomy improves survival for men with prostate cancer and adverse features. The optimal timing of radiation treatment, whether adjuvant or early salvage, remains under investigation.
Area of Science:
- Oncology
- Radiation Oncology
- Urologic Oncology
Background:
- Prostate cancer is a leading cause of cancer death in American men.
- Postoperative radiotherapy to the prostate bed after radical prostatectomy improves clinical outcomes for patients with adverse pathologic features.
Purpose of the Study:
- To review the evidence for adjuvant radiation treatment (ART) after prostatectomy.
- To distinguish ART from salvage radiation treatment (SRT).
- To discuss the optimal timing of post-prostatectomy radiation treatment (RT).
Main Methods:
- A comprehensive literature search was conducted in MEDLINE, including pre-MEDLINE databases.
Main Results:
- Adjuvant radiation treatment following prostatectomy reduces prostate-specific antigen (PSA) failure rates in patients with adverse pathologic factors.
- ART has the potential to significantly improve metastases-free and overall survival.
Conclusions:
- Adjuvant radiation treatment is beneficial for select prostate cancer patients post-prostatectomy.
- The survival benefit of early salvage radiation treatment compared to ART is still debated.
