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[Long-term effects of indapamide in left ventricular hypertrophy in patients with hypertension]
M Komajda1, K Klimczak, J Evans
1Hôpital Pitié-Salpêtrière, Paris.
Insights
Indapamide, a diuretic, effectively reduced left ventricular hypertrophy in patients with mild hypertension over 12 months. This finding suggests indapamide may help reverse cardiac changes associated with high blood pressure.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Research
Context:
- Left ventricular hypertrophy (LVH) is a significant cardiovascular risk factor in hypertensive patients.
- Understanding interventions for LVH regression is crucial for managing hypertension complications.
Purpose:
- To evaluate the efficacy of indapamide in regressing left ventricular hypertrophy in patients with mild hypertension.
- To compare indapamide's effects on LVH with other diuretics.
Summary:
- A 12-month open-label trial involving 9 patients with mild hypertension investigated indapamide's effect on LVH.
- Indapamide treatment led to a significant decrease in left ventricular mass index (LVMI) from 172 +/- 11 to 147 +/- 11 g/m2 (p < 0.001).
Impact:
- Indapamide demonstrates potential in inducing regression of left ventricular hypertrophy in hypertension.
- This suggests indapamide may offer advantages over other diuretics in managing hypertensive cardiac remodeling.
Abstract:
Left ventricular hypertrophy is a major and independent cardiovascular risk factor in hypertension. The effects of a diuretic, indapamide, on the regression of left ventricular hypertrophy were studied in a group of 9 patients with mild hypertension treated in an open therapeutic trial over a 12 month period. At the end of the trial, the left ventricular mass index decreased significantly from 172 +/- 11 to 147 +/- 11 g/m2 (p less than 0.001). Therefore, in contrast to the other diuretics which have been studied, indapamide seems able to induce regression of the left ventricular hypertrophy complicating hypertension.