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Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex

Emerson V Stewart1, Christine C Nwosu, Zongtian Tong

  • 1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Molecular Cell
|April 21, 2011
PubMed
Summary

Fission yeast uses a novel Golgi E3 ligase complex (Dsc) for sterol regulatory element binding protein (SREBP) cleavage, involving the ubiquitin-proteasome pathway. This differs from mammalian SREBP activation, suggesting a new protein degradation route.

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