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Related Experiment Videos

Reference values for ambulatory blood pressure: a meta-analysis.

J Staessen1, R Fagard, P Lijnen

  • 1Department of Pathophysiology, University of Leuven, Belgium.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|December 1, 1990
PubMed
Summary

This meta-analysis determined normal ambulatory blood pressure ranges. Average 24-hour readings are 117/72 mmHg, providing crucial clinical reference values.

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Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Trials

Background:

  • Establishing normal ambulatory blood pressure is essential for diagnosing and managing hypertension.
  • Previous studies have shown variability in normal ambulatory blood pressure values.
  • A comprehensive meta-analysis is needed to consolidate existing data and provide reliable reference ranges.

Purpose of the Study:

  • To conduct a meta-analysis of published studies to determine the mean and range of normal ambulatory blood pressure.
  • To establish reference values for 24-hour, daytime, and nighttime ambulatory blood pressure.
  • To provide updated guidelines for clinical practice in hypertension management.

Main Methods:

  • A systematic review and meta-analysis of 22 published studies.

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  • Inclusion of data from 2638 subjects.
  • Weighting of studies based on the number of subjects included.

    • Main Results:

    • The mean 24-hour ambulatory blood pressure was 117/72 mmHg.
    • Mean daytime pressure was 122/77 mmHg, and mean nighttime pressure was 106/64 mmHg.
    • The average range of normality (mean +/- 2 SD) was 97/57-137/87 mmHg over 24 hours.

    Conclusions:

    • The identified mean and range values for ambulatory blood pressure can serve as reference standards in clinical practice.
    • These estimates are valuable in the absence of prospective studies linking ambulatory blood pressure to cardiovascular outcomes.
    • Further research is warranted to correlate these ambulatory blood pressure ranges with cardiovascular morbidity and mortality.