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Updated: Jun 2, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Pustular psoriasis and drug-induced pustulosis
Summary
Drug-induced exanthematous pustulosis can mimic pustular psoriasis. Patch testing is valuable for diagnosing ciprofloxacin-induced eruptions, confirming drug causality.
Area of Science:
- Dermatology
- Clinical Pharmacology
Background:
- Exanthematous pustulosis presents diagnostic challenges, with flares potentially linked to pustular psoriasis or drug reactions.
- Distinguishing between these causes is crucial for appropriate patient management.
Observation:
- A 65-year-old female experienced recurrent exanthematous pustulosis flares.
- Two severe flares were specifically induced by ciprofloxacin, clinically and histologically resembling acute generalized exanthematous pustulosis.
Findings:
- Patch testing confirmed ciprofloxacin hypersensitivity.
- Positive reactions to other quinolones were also observed, indicating cross-reactivity.
Implications:
- Patch testing is a valuable diagnostic tool for identifying drug-induced exanthematous pustulosis.
- This case highlights the importance of considering drug reactions in pustular eruptions and utilizing patch testing for etiological diagnosis.
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