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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
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Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases

Refaat B Hamed1, J Ruben Gomez-Castellanos, Armin Thalhammer

  • 1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

Nature Chemistry
|April 21, 2011
PubMed
Summary

Protein engineering enables crotonase superfamily enzymes to catalyze stereoselective C-C bond formation for N-heterocycles. This advances synthetic organic chemistry using biocatalysis for enolate reactions.

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