[The algorithm for the biological treatment of depression in the Dutch multidisciplinary guideline on depression]

Although antidepressants are effective in the treatment of depression, nonresponse is unfortunately a recurring problem. Treatment algorithms can help the health care professional to make consecutive step-by-step choices between the different available treatment options.

To update the biological algorithm in the Dutch multidisciplinary guideline on the treatment of depression.

The literature was reviewed systematically.

There are five steps in the algorithm: 1. Treatment starts with an SSRI, a TCA, an SNRI, mirtazapine or buproprion. 2. If there is no response after 4-10 weeks, administer another antidepressant. 3. Augment medication with lithium. 4. Administer a monoamine oxidase inhibitor. 5. Apply electroconvulsive therapy.

The algorithm is certainly worth using, but its efficacy needs to be fully investigated.s.