Related Experiment Video
Updated: Jun 2, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Modulation of dysarthropneumophonia by low-frequency STN DBS in advanced Parkinson's disease
Caroline Moreau1, Odile Pennel-Ployart, Serge Pinto
1Service de neurologie et pathologie du mouvement, Université Lille Nord de France, France. caroline.moreau@chru-lille.fr
Background:
Parkinsonian dysarthria (as typically characterized by hypophonia, monotony of pitch, and rhythm abnormalities) is often accompanied by gait disturbances. The long-term effect of subthalamic nucleus deep brain stimulation (STN DBS) on dysarthria remains unclear.
Methods:
Given STN DBS's known improvement of gait disorders, we analyzed speech intelligibility and aerodynamic and acoustic parameters in 11 advanced PD patients in three double-blind, randomized conditions: "defined Off," 60 Hz STN DBS and 130 Hz STN DBS.
Results:
An improvement in aerodynamic speech parameters during 60 Hz STN DBS was accompanied by significant clinical benefit.
Conclusions:
Chronic treatment with low-frequency STN DBS may have a beneficial impact on dysarthropneumophonia, even in advanced PD patients.
More Related Videos
07:14A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
Published on: May 31, 2016
06:32Bringing the Clinic Home: An At-Home Multi-Modal Data Collection Ecosystem to Support Adaptive Deep Brain Stimulation
Published on: July 14, 2023
Related Concept Videos
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Neural Regulation
Parkinson Disease ll: Pathophysiology
Alterations in Muscle Tone lll
Parkinson's Disease: Overview
Parkinson Disease l: Introduction