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[Preparation of xiongbing microemulsion and its quality evaluation]
Lisheng Wang1, Qi Guo, Yingfeng Zhang
1College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. wlis68@126.com
Objective:
To study the preparation of xiong-bing microemulsion (XB ME) and its quality evaluation.
Method:
XB ME was prepared by using the methods of titration to prepare the Pseudo-ternary phase diagram. The stability and size distribution of XB ME were tested. The contents of TMP and FA in ME were determined by HPLC method.
Result:
The character of XB ME was stable. The average diameter was 17.6 nm, and a uniform distribution of particle size were achieved. The solubility of TMP in ME was 2.6 g x L(-1), the methodological average recovery was 97.0% with RSD of 1.5% (n=6); The solubility of FA in ME was 0.3 g x L(-1), the methodological average recovery was 95.9% with RSD of 1.9% (n=6).
Conclusion:
The results indicated that the quality of XB ME was stable. The method to determine the contents of TMP and FA was accurate and reliable.