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Colonic mucosal lesions associated with low-dose aspirin: a case control study
Tomoyoshi Shibuya1, Toshifumi Ohkusa, Tetsuji Yokoyama
1Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan. tomoyosi@juntendo.ac.jp
Scandinavian Journal of Gastroenterology
|April 22, 2011
Summary
Long-term low-dose aspirin (LDA) use is linked to increased colonic mucosal lesions, particularly in females. Physicians should consider this risk when prescribing LDA, especially for women.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Low-dose aspirin (LDA) is frequently prescribed to reduce vascular event risk in patients with atherosclerosis.
- Recent trends show a significant rise in LDA prescriptions.
Purpose of the Study:
- To investigate the association between long-term low-dose aspirin use and the risk of colonic mucosal lesions.
- To analyze potential gender-specific differences in this risk.
Main Methods:
- A colonoscopy study involving 199 colitis cases and 5764 controls in Japan (2004-2006).
- Comparison of LDA use history between cases and controls.
- Multivariate logistic regression analysis adjusted for age, sex, and underlying diseases.
Main Results:
- The overall adjusted odds ratio for colonic mucosal lesions with LDA use was 1.45 (not statistically significant).
- A significantly increased odds ratio for LDA-induced colitis was observed in females (2.55, p=0.006).
- No significant increase in risk was found in males (0.70, p=0.334).
Conclusions:
- Low-dose aspirin use is associated with an increased risk of colonic mucosal lesions in females.
- LDA may play a role in the pathogenesis of colonic ulceration or colitis.
- Healthcare providers should be aware of LDA-associated colonic risks, especially in female patients.
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