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Updated: Jun 2, 2026
09:03
Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development
Published on: June 19, 2018
Does adjuvanticity depend on the ability to recruit specific immune cells?
1Vaccine and Infectious Disease Organization and Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada. volker.gerdts@usask.ca
Expert Review of Vaccines
|April 22, 2011
Summary
Vaccine adjuvants alum and MF59 rapidly recruit neutrophils and monocytes to injection sites. These cells transport antigens to lymph nodes, but their exact role in adaptive immunity requires further investigation.
Area of Science:
- Immunology
- Vaccinology
Background:
- Vaccine adjuvants enhance immune responses by recruiting immune cells.
- Mechanisms of immune cell recruitment by adjuvants are not fully understood.
Discussion:
- Alum and MF59 adjuvants induce rapid, significant neutrophil and monocyte influx at the injection site.
- Neutrophils rapidly transport antigens to draining lymph nodes.
- Despite neutrophil recruitment and antigen transport, their ablation did not affect adaptive immunity.
Key Insights:
- Neutrophils play a role in antigen transport following vaccination.
- The function of neutrophils in adaptive immunity induction may be redundant or compensated by other immune cells.
- Dendritic cells, macrophages, eosinophils, and monocytes are also recruited.
Outlook:
- Further research is needed to elucidate the compensatory mechanisms for neutrophil function in adaptive immunity.
- Investigating the specific roles of other recruited immune cells is warranted.
- Understanding these recruitment dynamics can optimize vaccine adjuvant design.
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