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p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress

Annalisa Natalicchio1, Federica Tortosa, Sebastio Perrini

  • 1Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari School of Medicine, Bari, Italy.

Archives of Physiology and Biochemistry
|April 22, 2011
PubMed

Insights

The p66Shc protein influences glucose transport and oxidative stress. Its role in these processes suggests it could be a therapeutic target for type 2 diabetes.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Metabolic Diseases

Background:

  • p66Shc is a 66 kDa adaptor protein involved in receptor tyrosine kinase signaling.
  • The p66Shc isoform regulates the Erk pathway in skeletal muscle, impacting actin polymerization and glucose transport.
  • p66Shc also functions as an oxidative stress sensor, linked to apoptosis and longevity via Ser36 phosphorylation.

Purpose of the Study:

  • To investigate the role of p66Shc in the context of oxidative stress and metabolic diseases.
  • To explore p66Shc as a potential therapeutic target for type 2 diabetes.

Main Methods:

  • Analysis of p66Shc expression and function.
  • Investigating the link between p66Shc, oxidative stress, and cellular signaling pathways.
  • Examining the relevance of p66Shc in models of metabolic dysfunction.

Main Results:

  • p66Shc plays a role in regulating glucose transport in skeletal muscle myoblasts.
  • p66Shc acts as a sensor for oxidative stress, influencing apoptosis.
  • Altered p66Shc expression or function may contribute to type 2 diabetes pathogenesis.

Conclusions:

  • p66Shc is implicated in key cellular processes relevant to metabolic health.
  • Targeting p66Shc may offer a novel therapeutic strategy for type 2 diabetes.
  • Further research into p66Shc's role in oxidative stress and metabolism is warranted.

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