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Published on: August 9, 2016
A multicenter study on extramammary Paget's disease in Korea
Seok-Jong Lee1, Yoon Seok Choe, Hong Dae Jung
1Department of Dermatology, Kyungpook National University, Daegu, Korea.
International Journal of Dermatology
|April 22, 2011
Summary
Extramammary Paget's disease (EMPD) in Korea shows male predominance and a high malignancy association rate (14.4%). Mohs surgery resulted in lower recurrence rates compared to conventional excision for EMPD patients.
Area of Science:
- Dermatology
- Oncology
Background:
- Extramammary Paget's disease (EMPD) research is limited in Asian populations.
- This study addresses the lack of data on EMPD in Korea.
Purpose of the Study:
- To investigate the clinicopathological features of EMPD in Korean patients.
- To determine the biological behavior and treatment outcomes for EMPD.
- To assess the association of EMPD with other malignancies.
Main Methods:
- A multicenter study involving 194 Korean patients over five years.
- Clinicopathological data, treatment modalities, and follow-up information were collected.
- Modified Chanda's guidelines were used to assess malignancy association.
Main Results:
- EMPD demonstrated a male predominance (3.9:1).
- A significant association with malignancy was found in 14.4% of patients, including gastrointestinal cancers.
- Local recurrence rates were 28.6%, with Mohs surgery showing a lower recurrence rate (12.5%) than conventional excision (33.3%).
Conclusions:
- Korean EMPD cases share clinical features with other Asian populations, notably gender predominance.
- The rate of associated malignancy in Korean EMPD patients is higher than reported in other Asian studies.
- Mohs surgery may offer better local control for EMPD compared to conventional excision.
