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Updated: Jun 2, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
In touch with psoriasis: topical treatments and current guidelines
1National Photobiology Unit Beaumont & Mater Hospitals, Dermatology Department, Beaumont Hospital, Dublin, Ireland. gillianmmurphy@gmail.com
Summary
Topical vitamin D analogues and corticosteroids, especially in combination, are highly effective for mild-to-moderate psoriasis. This fixed combination offers greater convenience and fewer side effects for long-term treatment.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Therapeutics
Background:
- Psoriasis treatment selection is challenging due to disease variability.
- Topical therapies are preferred for mild-to-moderate psoriasis.
- Newer topical agents offer improved convenience and safety profiles.
Purpose of the Study:
- To review topical therapies and treatment guidelines for psoriasis.
- To highlight the efficacy of vitamin D analogues and corticosteroids.
- To discuss current international treatment recommendations.
Main Methods:
- Review of a satellite symposium presentation.
- Analysis of a Cochrane review on psoriasis treatments.
- Discussion of US and German treatment guidelines.
Main Results:
- Vitamin D analogues and topical corticosteroids demonstrate high efficacy in randomized clinical trials.
- A fixed combination of calcipotriol (a vitamin D analogue) and betamethasone dipropionate (a corticosteroid) shows superior efficacy compared to monotherapy.
- This combination is suitable for intermittent long-term treatment of mild-to-moderate psoriasis.
Conclusions:
- Current US and German guidelines recommend vitamin D analogues and corticosteroids for mild-to-moderate psoriasis.
- Combination therapy with calcipotriol and betamethasone dipropionate is a highly effective and safe option.
- Evidence supports the use of this combination for managing mild-to-moderate psoriasis.
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