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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: Jun 2, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Introduction--Epiphanies in epigenetics.

Xiaodong Cheng1, Robert M Blumenthal

  • 1Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.

Progress in Molecular Biology and Translational Science
|April 22, 2011
PubMed
Summary
This summary is machine-generated.

The epigenetic code, involving DNA and histone modifications, regulates gene expression. This study explores how these epigenetic marks are maintained during cell division, ensuring inheritance of gene expression patterns.

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Methylated DNA Immunoprecipitation
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Methylated DNA Immunoprecipitation

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Area of Science:

  • Epigenetics and Gene Regulation
  • Molecular Biology
  • Cellular Mechanisms

Background:

  • The combinatorial pattern of DNA and histone modifications forms an epigenetic code influencing gene expression.
  • Epigenetic status is modulated by noncoding RNAs and remodeling complexes.
  • DNA methylation is linked to specific histone modifications like H3K4me0 and H3K9m.

Purpose of the Study:

  • To discuss protein domains (ADD, CXXC, MBD, SRA) involved in linking DNA and histone methylation.
  • To examine the domain structure of DNMT1 and UHRF1 in mammalian cells.
  • To discuss mechanisms for maintaining coordinated DNA and histone methylation during cell division.

Main Methods:

  • Review and discussion of existing literature on epigenetic modifications and protein domains.
  • Analysis of the structural and functional roles of key proteins in epigenetic maintenance.
  • Exploration of mechanisms for epigenetic pattern inheritance during mitosis.

Main Results:

  • Identified key protein domains (ADD, CXXC, MBD, SRA) that bridge DNA and histone methylation.
  • Detailed the domain organization of DNA methyltransferase DNMT1 and its partner UHRF1.
  • Proposed a mechanism for the coordinated maintenance of DNA and histone methylation across cell division.

Conclusions:

  • The epigenetic code is crucial for regulating gene expression.
  • Specific protein domains and their interactions are essential for integrating DNA and histone methylation.
  • Coordinated maintenance of epigenetic marks ensures faithful inheritance of transcriptional potential during cell division.