Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meta-analysis of the association between HLA-G 14-bp insertion/deletion polymorphism and susceptibility to viral infections and cancer risk.

Human immunology·2026
Same author

HLA-E gene polymorphism and expression in colorectal cancer patients.

Human immunology·2026
Same author

Study of the association of LILRB2 gene polymorphisms with colorectal cancer susceptibility and prognosis in Tunisian population.

Human immunology·2025
Same author

Editorial: Novel reliable approaches for prediction and clinical decision-making in cancer.

Frontiers in immunology·2025
Same author

Associations of HLA-G 3'UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis.

Immunobiology·2024
Same author

The 14-bp insertion/deletion as a promising gene polymorphism to understand cancer risk: Evidence from a systematic review and comprehensive meta-analysis.

Heliyon·2024

Related Experiment Video

Updated: Jun 2, 2026

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

HLA-G as predisposing for metastasis.

Ines Zidi1, Nidhal Ben Amor

  • 1Laboratory of Biochemistry, Research Unit 02/UR/09-01, Higher Institute of Biotechnology of Monastir, Tunisia. ines.zidi@techemail.com

Medical Hypotheses
|April 22, 2011
PubMed
Summary

Human leukocyte antigen-G (HLA-G) is linked to immune tolerance and cancer metastasis. Understanding HLA-G's role in metastasis may improve cancer therapies and reduce relapses.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Human leukocyte antigen-G (HLA-G) is a non-classical MHC class I molecule.
  • HLA-G is highly expressed in various cancer pathologies.
  • Emerging evidence suggests HLA-G's role in immune tolerance may link it to cancer metastasis.

Purpose of the Study:

  • To explore the potential mechanisms connecting HLA-G regulation and the metastatic cascade.
  • To investigate HLA-G's involvement in cancer initiation, progression, and virulence.

Main Methods:

  • Literature review and analysis of existing evidence on HLA-G and metastasis.
  • Hypothesizing molecular and cellular pathways involved in HLA-G-mediated metastasis.

Main Results:

More Related Videos

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jun 2, 2026

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
08:27

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
07:45

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

  • HLA-G expression is associated with immune evasion in cancer.
  • Proposed mechanisms suggest HLA-G influences multiple stages of metastasis.
  • Further research is needed to validate these proposed links.

Conclusions:

  • HLA-G may play a significant role in promoting cancer metastasis.
  • Understanding HLA-G's function in metastasis could lead to novel therapeutic strategies.
  • Targeting HLA-G might offer a way to limit cancer relapses and metastasis.