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Updated: Jun 2, 2026

Establishment of an Extracellular Acidic pH Culture System
Published on: November 19, 2017
A practical approach to understanding acid-base abnormalities in critical illness
Amy L Dzierba1, Prasad Abraham
1NewYork-Presbyterian Hospital, Columbia University, New York, NY, USA. ald9012@nyp.org
Critically ill patients often have acid-base disorders. This review explains acid-base physiology and provides a systematic method for evaluating and managing these disturbances using arterial blood gas analysis.
Area of Science:
- Critical care medicine
- Physiology
- Clinical pathology
Background:
- Acid-base disorders are frequent complications in critically ill patients.
- Arterial blood gas analysis is a key diagnostic tool for assessing these disorders.
- Effective management requires understanding acid-base physiology and regulation.
Observation:
- A systematic problem-solving approach aids in identifying acid-base abnormalities.
- This approach helps in assessing the progression and severity of metabolic and respiratory issues.
- Evaluating patients with acid-base disorders necessitates a structured methodology.
Findings:
- The review examines the core principles of acid-base physiology and the body's regulatory mechanisms.
- It presents a clear method for evaluating complex acid-base disturbances.
- Diagnostic criteria and therapeutic strategies for various acid-base disorders are discussed.
Implications:
- Implementing a systematic approach can improve the diagnosis and management of acid-base disorders.
- Enhanced understanding facilitates timely and appropriate therapeutic interventions.
- This review serves as a guide for clinicians managing critically ill patients with acid-base imbalances.
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