Related Experiment Video

Updated: Jun 2, 2026

Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding
06:10

Accessible Silicone Chip-to-Membrane Sealing Procedure for Flexible, Reliable Bonding

Published on: March 20, 2026

Considerations in membrane resealing after preterm PROM

Vanita Dharan Jain1, Anthony Sciscione

  • 1Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, Delaware Center for Maternal Fetal Medicine, Christiana Hospital, Newark, Delaware, USA.

Clinical Obstetrics and Gynecology
|April 22, 2011
PubMed

Insights

Understanding the biomechanics of fetal membranes is crucial for preventing preterm premature rupture of membranes (PPROM). Research into membrane healing and rupture prevention strategies is needed.

Area of Science:

  • Obstetrics and Gynecology
  • Biomedical Engineering
  • Maternal-Fetal Medicine

Background:

  • Current management for preterm premature rupture of membranes (PPROM) relies on expectant management, antibiotics, and steroid therapy.
  • Membrane rupture is increasingly viewed as a mechanical event, necessitating a deeper understanding of fetal membrane physical properties.

Purpose of the Study:

  • To review membrane mechanics, healing advancements, and prevention strategies for PPROM.
  • To highlight the need for biomechanical models to elucidate PPROM mechanisms and inform interventions.

Main Methods:

  • Literature review of current PPROM management.
  • Analysis of studies on fetal membrane biomechanics and healing.
  • Discussion of potential prevention strategies based on mechanical properties.

Main Results:

  • Physiologic mechanisms underlying PPROM remain incompletely understood.
  • Mechanical factors are significant contributors to membrane rupture.
  • Biomechanical modeling offers a promising avenue for research.

Conclusions:

  • Further investigation into the biomechanics of fetal membranes is essential for understanding PPROM.
  • Developing strategies for membrane repair and prevention requires a biomechanical approach.
  • Integrating biomechanical insights could revolutionize PPROM management.

More Related Videos

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage07:51

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

Published on: November 4, 2010

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Related Concept Videos

Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections with a...
What are Membranes?01:54

What are Membranes?

A key characteristic of life is the ability to separate the external environment from the internal space. To do this, cells have evolved semi-permeable membranes that regulate the passage of biological molecules. Additionally, the cell membrane defines a cell’s shape and interactions with the external environment. Eukaryotic cell membranes also serve to compartmentalize the internal space into organelles, including the endomembrane structures of the nucleus, endoplasmic reticulum and Golgi...