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Updated: Jun 2, 2026
09:09
Gene Expression Analyses in Human Follicles
Published on: February 17, 2023
Mechanisms of follicle selection and development
1MUHC Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada. weon-young.son@muhc.mcgill.ca
Minerva Ginecologica
|April 22, 2011
Summary
The dominant follicle (DF) is selected through complex hormonal and cellular mechanisms, escaping atresia to prepare for ovulation. Understanding DF selection is key for optimizing oocyte retrieval in fertility treatments.
Area of Science:
- Reproductive Endocrinology
- Ovarian Physiology
- Folliculogenesis
Background:
- Follicle selection is crucial for ovulation in monovulatory species, including humans.
- The dominant follicle (DF) uniquely avoids atresia and develops towards ovulation.
- Understanding DF selection mechanisms is vital for reproductive health and fertility treatments.
Purpose of the Study:
- To elucidate the intricate mechanisms governing dominant follicle selection.
- To explore the roles of hormones like FSH, LH, and IGF, and factors like AMH in DF development.
- To assess the implications of DF selection knowledge for in-vitro maturation (IVM) protocols.
Main Methods:
- Review and synthesis of proposed mechanisms for DF selection.
- Analysis of hormonal regulation (FSH, LH) and growth factors (IGF) in folliculogenesis.
- Examination of the role of Anti-Müllerian hormone (AMH) and vascularization in follicle fate.
Main Results:
- DF selection involves FSH dynamics, cohort attrition, and acquisition of FSH-independence.
- A transition from FSH- to LH-dependence is proposed for continued DF development.
- AMH levels decrease with follicle growth, and differential vascularization may play a role.
Conclusions:
- DF selection is a multifactorial process involving hormonal interplay and specific molecular signals.
- Knowledge of DF selection can inform optimal oocyte retrieval timing in IVM.
- Further research into DF selection may enhance the efficacy of assisted reproductive technologies.
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