Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Structure of N-methylnicotinamide.

T Srikrishnan¹, R Parthasarathy

¹Center for Crystallographic Research, Roswell Park Cancer Institute, Buffalo, New York 14263.

Acta Crystallographica. Section C, Crystal Structure Communications

|September 15, 1990

Summary

This study details the crystal structure of a pyridine derivative, revealing its molecular arrangement and intermolecular hydrogen bonding. The findings provide insights into the solid-state behavior of this compound.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comment on "Does pelvic fixation impact reoperation outcomes for neuromuscular scoliosis surgery? A 10-year matched cohort analysis".

Spine deformity·2026

Same author

Vestibular schwannoma unveiled by pregnancy: A case report and literature review.

European journal of obstetrics, gynecology, and reproductive biology·2024

Same author

Postoperative respiratory depression caused by iatrogenic hypermagnesaemia.

Anaesthesia reports·2022

Same author

Design and development of heater control circuit without temperature sensor for monitoring hydrogen in argon.

The Review of scientific instruments·2022

Same author

Bio inspired growth factor loaded self assembling peptide nano hydrogel for chronic wound healing.

International journal of biological macromolecules·2021

Same author

An Unusual Association of Renal Cell Carcinoma and Renal Malakoplakia with Focal Segmental Glomerulosclerosis in an Elderly Patient.

Indian journal of nephrology·2019

Area of Science:

Crystallography
Chemical Physics
Organic Chemistry

Background:

Understanding the solid-state structure of organic molecules is crucial for predicting their physical and chemical properties.
Pyridine derivatives are important in various fields, including pharmaceuticals and materials science.
Detailed structural analysis can elucidate intermolecular interactions that influence bulk properties.

Purpose of the Study:

To determine the precise crystal structure of the N-methylcarboxamide pyridine derivative.
To analyze the molecular conformation, including bond lengths, angles, and dihedral angles.
To investigate the intermolecular interactions, specifically hydrogen bonding, present in the crystal lattice.

Main Methods:

Single-crystal X-ray diffraction was employed to collect diffraction data.
The crystal structure was solved and refined using standard crystallographic techniques.
Unit cell parameters, atomic coordinates, and thermal parameters were determined.

Main Results:

The compound crystallizes in the monoclinic space group P2(1)/a with specific unit cell dimensions.
The N-methylcarboxamide group exhibits an extended conformation with defined torsional angles.
A dihedral angle of 22 degrees was observed between the pyridine ring and the carboxamide plane.
N-H...O hydrogen bonds were identified, linking molecules via amino and carbonyl groups.

Conclusions:

The crystal structure of the N-methylcarboxamide pyridine derivative has been successfully elucidated.
The observed molecular conformation and intermolecular hydrogen bonding provide a basis for understanding its solid-state properties.
This structural data serves as a valuable reference for further studies on related compounds.

Related Experiment Videos