Related Experiment Video

Updated: Jun 2, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Serum level of heart-type Fatty Acid-binding protein in patients with chronic renal failure

Hafidh A Al-Hadi1, Brent William, Keith A Fox

  • 1Department of Medicine, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman;

Sultan Qaboos University Medical Journal
|April 22, 2011
PubMed

Insights

Heart-type fatty acid binding-protein (H-FABP) and cardiac troponin (cTnT) levels are elevated in patients with renal failure. This suggests their diagnostic efficiency for acute myocardial infarction (AMI) may be limited in this population.

Area of Science:

  • Cardiovascular Biomarkers
  • Renal Medicine
  • Clinical Diagnostics

Background:

  • Heart-type fatty acid binding-protein (H-FABP) is a potential early diagnostic marker for acute myocardial infarction (AMI).
  • The impact of kidney disease on H-FABP levels is not well understood.
  • Renal failure may affect the interpretation of cardiac biomarkers.

Purpose of the Study:

  • To compare H-FABP and cardiac troponin (cTnT) concentrations in patients with renal failure.
  • To evaluate the influence of renal failure on these cardiac biomarkers.

Main Methods:

  • A cohort of 16 patients with renal failure undergoing dialysis was studied.
  • Serum levels of H-FABP and cTnT were measured.

Main Results:

  • All patients (100%) showed elevated H-FABP levels (mean ±SD: 81 ±53.3μg/L).
  • Elevated cTnT levels (≥ 0.1μg/L) were observed in 50% of patients.
  • Significant renal dysfunction was confirmed by high urea and creatinine levels.

Conclusions:

  • H-FABP and cTnT may have limited diagnostic value for AMI in patients with renal failure.
  • Elevated levels of these biomarkers can occur in renal failure patients even without AMI.
Abstract

Keywords:
Cardiac troponin THeart-type fatty acid-binding proteinRenal failure

More Related Videos

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...