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Updated: Jun 2, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Current methods for asymmetric halogenation of olefins
Alejandro Castellanos1, Stephen P Fletcher
1Department of Chemistry, Chemical Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
This review covers advances in asymmetric halogenation of olefins, providing a reference for current methods and mechanistic insights. It details the state-of-the-art, scope, and limitations of these crucial synthetic reactions.
Area of Science:
- Organic Chemistry
- Asymmetric Synthesis
- Catalysis
Background:
- Olefin functionalization is a cornerstone of organic synthesis.
- Developing enantioselective methods for halogenation remains a significant challenge.
- Asymmetric halogenation offers a direct route to chiral halogenated compounds.
Purpose of the Study:
- To review and synthesize the progress in asymmetric olefin halogenation.
- To provide a comprehensive reference for researchers in the field.
- To discuss the current state-of-the-art, scope, and limitations of existing methodologies.
Main Methods:
- Literature review of reported asymmetric halogenation reactions.
- Analysis of mechanistic studies to understand reaction pathways.
- Categorization of methods based on catalysts, reagents, and substrate scope.
Main Results:
- Compilation of various catalytic systems for asymmetric halogenation.
- Discussion of different halogenating agents and their applications.
- Highlighting key advancements in controlling stereoselectivity.
Conclusions:
- Asymmetric olefin halogenation has seen substantial progress.
- Further research is needed to expand the scope and overcome limitations.
- These methods are vital for accessing valuable chiral building blocks.
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