Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Stress hypertension in monkeys.

J Kunes¹, A N Demin, J Jelínek

¹Institute of Physiology, Czechoslovak Academy of Sciences, Prague.

Physiologia Bohemoslovaca

|January 1, 1990

Summary

Chronic forelimb immobilization in monkeys caused sustained hypertension. This low-renin hypertension was linked to reduced plasma volume, not renin-angiotensin system activation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Kondo quasiparticle dynamics observed by resonant inelastic x-ray scattering.

Nature communications·2022

Same author

Pressure-Induced Excitations in the Out-of-Plane Optical Response of the Nodal-Line Semimetal ZrSiS.

Physical review letters·2021

Same author

An anthropogenic model of cardiovascular system adaptation to the Earth's gravity as the conceptual basis of pathological anthropology.

Journal of physiological anthropology·2021

Same author

Cholecystokinin system is involved in the anorexigenic effect of peripherally applied palmitoylated prolactin-releasing peptide in fasted mice.

Physiological research·2021

Same author

Pathophysiology of NAFLD and NASH in Experimental Models: The Role of Food Intake Regulating Peptides.

Frontiers in endocrinology·2020

Same author

Genome-wide DNA methylation analysis identifies promoter hypermethylation in canine malignant melanoma.

Research in veterinary science·2020

Area of Science:

Physiology
Cardiovascular Research
Primate Models

Background:

Understanding the physiological effects of altered movement and posture on blood pressure regulation is crucial.
Immobilization can lead to significant physiological changes, but its long-term impact on hypertension is not fully understood.

Purpose of the Study:

To investigate the influence of chronic forelimb immobilization in an upright position on blood pressure in monkeys.
To determine the underlying mechanisms, including the role of the renin-angiotensin system and extracellular fluid compartments, in this induced hypertension.

Main Methods:

Monkeys underwent chronic forelimb immobilization for 6 months, enforcing upright posture.
Blood pressure (systolic and diastolic) was monitored in awake and anesthetized states.
Plasma renin concentration and extracellular fluid volumes (plasma and interstitial) were assessed in the chronic stage (15 months).

Main Results:

Immobilized monkeys developed sustained hypertension, with a ~30% increase in both systolic and diastolic pressures.
Hypertension persisted even after normal movement was restored.
In the chronic stage, plasma renin concentration decreased by 55%, and plasma volume diminished by 18%.

Conclusions:

Chronic forelimb immobilization induces a persistent low-renin hypertension in monkeys.
The observed changes in extracellular fluid compartments resemble those seen in hypovolemic hypertension.
The renin-angiotensin system does not appear to be activated in maintaining this hypertensive state.

Related Experiment Videos