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[Hypertension in the aged: some peculiarities of pathogenesis]

N K Gorshunova, E V Tereshina, D N Ukraintseva

    Advances in Gerontology = Uspekhi Gerontologii
    |April 23, 2011
    PubMed

    Insights

    Elevated adipose tissue in older adults may drive pathological changes in heart and carotid arteries. This study links inflammation and oxidative stress to age-related hypertension and vascular remodeling.

    Area of Science:

    • Cardiovascular Medicine
    • Gerontology
    • Metabolic Research

    Context:

    • Hypertension is a prevalent condition in the elderly, often associated with significant vascular and cardiac structural changes.
    • Age-related physiological shifts can alter homeostasis, impacting cardiovascular health.
    • Understanding the mechanisms behind age-associated cardiovascular remodeling is crucial for effective management.

    Purpose:

    • To investigate the features of hypertension in the aged by examining myocardial and common carotid artery structure.
    • To assess the roles of lipid metabolism, oxidant systems, and inflammation markers in elderly hypertensive patients.
    • To explore the link between increased adipose tissue mass and the transition of adaptive vascular remodeling to a pathological state.

    Summary:

    • This study analyzed lipid metabolism, oxidant system parameters, and inflammation markers in healthy individuals and hypertensive patients aged 60-74.
    • Findings suggest that elevated adipose tissue mass contributes to age-associated pathological remodeling of the myocardium and carotid arteries.
    • Myocardial thickening results from cardiomyocyte proliferation, while carotid artery wall changes are linked to inflammation and lipid peroxidation.

    Impact:

    • Identifies hydrogen peroxide and nitric oxide as potential markers of oxidative stress in age-dependent homeostasis changes.
    • Provides insights into the pathological mechanisms of hypertension in the elderly, specifically vascular and myocardial remodeling.
    • Suggests a potential therapeutic target by highlighting the role of adipose tissue in driving adverse cardiovascular changes with aging.

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