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Comorbidities in cluster headache and migraine
Jasna J Zidverc-Trajkovic1, Tatjana D Pekmezovic, Ana L Sundic
1Headache Center, Institute of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. jzidverc@gmail.com
Acta Neurologica Belgica
|April 23, 2011
Summary
Cluster headache (CH) patients frequently have comorbid diseases, similar to migraine patients. However, CH is significantly more associated with chronic sinusitis and diabetes mellitus.
Area of Science:
- Neurology
- Epidemiology
- Internal Medicine
Background:
- Cluster headache (CH) and migraine are primary headache disorders with significant patient populations.
- Understanding comorbid conditions is crucial for comprehensive patient management and research.
Purpose of the Study:
- To investigate and compare the prevalence of comorbid diseases in patients diagnosed with cluster headache (CH) versus migraine.
- To identify specific conditions that are more frequently associated with CH compared to migraine.
Main Methods:
- Retrospective analysis of 130 CH patients and 982 migraine patients diagnosed using ICHD-II criteria over eight years.
- Medical records were reviewed for comorbid diseases, coded using the ICD, X revision.
- Logistic regression analyses were used to calculate odds ratios (OR) and 95% confidence intervals (95% CI) for comorbid conditions.
Main Results:
- Comorbid disorders were present in 56.9% of CH patients and 56.7% of migraine patients.
- Chronic sinusitis, malignancy, diabetes mellitus, glaucoma, and other primary headache disorders were more frequent in CH patients.
- Multivariate analysis revealed chronic sinusitis (OR=7.6) and diabetes mellitus (OR=4.2) were significantly more associated with CH than migraine, even after adjusting for confounders.
Conclusions:
- Comorbid conditions are common in CH patients, with a prevalence similar to that observed in migraine patients.
- Chronic sinusitis and diabetes mellitus represent key distinct comorbidities more frequently observed in cluster headache patients.
- These findings highlight the importance of screening for specific comorbidities in CH patients.
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