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Rosai-Dorfman syndrome: a case report
Satchidananda Panda1, Ritam Ray, Dipti Kanta Dora
1Department of ENT and Head and Neck Surgery, SCB Medical College and Hospital, Cuttack 753007.
Journal of the Indian Medical Association
|April 23, 2011
Summary
A woman with persistent neck swellings and nasal blockage was diagnosed with a rare condition. Histopathology revealed foamy histiocytes, indicating an unusual immune response.
Area of Science:
- Immunology
- Pathology
- Otolaryngology
Background:
- A 30-year-old female presented with a 3-month history of febrile illness and multiple neck swellings.
- The patient also experienced nasal blockade, suggesting upper respiratory or sinonasal involvement.
Observation:
- Physical examination revealed non-tender, non-matted neck swellings, each measuring 4-5 cm.
- A CT scan of the nose and paranasal sinuses identified a mass within the right nasal cavity.
Findings:
- Cervical lymph node histopathology demonstrated large clusters of mononuclear foamy histiocytes.
- Emperipolesis, specifically lymphophagocytosis, was observed in some of these histiocytes.
Implications:
- This case highlights a rare presentation requiring careful histopathological evaluation.
- Treatment involved antibiotics and prednisolone, suggesting an inflammatory or infectious etiology.
- Further research into the pathogenesis and optimal management of such conditions is warranted.
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