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Updated: Jun 2, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
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Teflon-coated silicon microreactors: impact on segmented liquid-liquid multiphase flows.

Simon Kuhn1, Ryan L Hartman, Mahmooda Sultana

  • 1Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|April 23, 2011
PubMed
Summary
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Fluoropolymer modification of silicon microreactors switches wetting properties from hydrophilic to hydrophobic. This improves control over multiphase flows and residence time distributions for synthesis and screening applications.

Area of Science:

  • Chemical Engineering
  • Materials Science
  • Microfluidics

Background:

  • Silicon microreactors are crucial for chemical synthesis.
  • Controlling wetting properties is essential for optimizing multiphase flows.
  • Existing microreactor surfaces often exhibit hydrophilic characteristics, limiting flow control.

Purpose of the Study:

  • To modify silicon microreactors with fluoropolymers to control wetting properties.
  • To investigate the impact of these modifications on liquid-liquid multiphase flows.
  • To enhance residence time distribution control for synthesis and screening.

Main Methods:

  • Fluoropolymer modification using Teflon AF dispersion and controlled solvent evaporation.
  • Characterization of polymer layer thickness using microscopy.

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  • Analysis of multiphase flows using residence time distribution measurements and particle image velocimetry.

    • Main Results:

    • Hydrophilic surfaces were successfully converted to hydrophobic surfaces.
    • Fluoropolymer coating resulted in a polymer layer thickness ranging from 1 to 13 μm.
    • PTFE-coated microreactors showed reduced axial dispersion in segmented liquid-liquid flows.
    • Changes in segment shape and velocity fluctuations were observed, narrowing segment size distribution.

    Conclusions:

    • Fluoropolymer modification offers effective control over microreactor wetting properties.
    • Hydrophobic surfaces enhance control over multiphase flow behavior and reduce axial dispersion.
    • Modified microreactors provide improved residence time distribution control for advanced synthesis and screening.