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Updated: Jun 2, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Targeted therapies in bone sarcomas: current approach and future directions
Jessica Lee Yarber1, Mark Agulnik
1Northwestern Memorial Hospital, Internal Medicine, Chicago, IL 60611, USA. yarberjl@gmail.com
Introduction:
Bone sarcomas are rare malignancies and once advanced, there is limited response to current chemotherapeutic regimens. Targeted therapies could have substantial impact on these diseases.
Areas Covered:
Specific molecular targets of bone sarcomas are reviewed along with the various targeted therapies that have potential to change the outcome of these chemotherapy resistant diseases.
Expert Opinion:
There are promising pathways identified that targeted inhibitors could provide better treatment options for metastatic bone sarcomas. There is a strong need for continued Phase II and III clinical trials investigating these molecularly targeted therapies.
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