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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

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Related Experiment Video

Updated: Jun 2, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
06:38

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

The International Stroke Trial database.

Peter A G Sandercock1, Maciej Niewada, Anna Członkowska

  • 1Department of Clinical Neurosciences, University of Edinburgh, Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK. Peter.Sandercock@ed.ac.uk

Trials
|April 23, 2011
PubMed
Summary

The International Stroke Trial (IST) dataset, including 19,435 patients, is now publicly available for future stroke research. This valuable data resource can inform trial planning, especially for older populations and in resource-limited settings.

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Area of Science:

  • Clinical Neurology
  • Epidemiology
  • Medical Informatics

Background:

  • The International Stroke Trial (IST) was one of the largest randomized trials in acute stroke.
  • Limited background stroke care and no thrombolytic therapy were administered to patients.

Purpose of the Study:

  • To make individual patient data from the IST publicly available.
  • To facilitate future clinical trial planning and secondary analyses in stroke research.

Main Methods:

  • Extracted data for each randomized patient, including variables at randomization, 14-day outcomes, and 6-month follow-up.
  • Compiled data into an analysable database for public use.

Main Results:

  • The IST dataset comprises 19,435 acute stroke patients with 99% follow-up.
  • Over 26.4% of patients were older than 80 years at study entry.

Conclusions:

  • The IST dataset serves as a primary data source for planning future stroke trials and sample size calculations.
  • The data is particularly relevant for trials involving elderly patients and for research in resource-poor settings.