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Urinary 11-dehydro thromboxane B₂ levels in type 2 diabetic patients before and during aspirin intake

Lillian Harboe Gonçalves1, Luci Maria Sant'ana Dusse, Ana Paula Fernandes

  • 1Department of Clinical and Toxicological Analysis-Faculty of Pharmacy-Federal University of Minas Gerais, Belo Horizonte, Brazil.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 23, 2011
PubMed

Insights

Aspirin significantly reduced urinary 11-dehydro thromboxane (11-dhTXB₂) in type 2 diabetic patients, but effectiveness varied. Higher BMI was linked to better aspirin response, suggesting personalized prevention strategies for cardiovascular events.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Type 2 diabetes increases cardiovascular event risk, often managed with aspirin for primary prevention.
  • Urinary 11-dehydro thromboxane (11-dhTXB₂) measures aspirin's antiplatelet effect and identifies cardiovascular risk.
  • Investigating aspirin's efficacy in type 2 diabetes is crucial for optimizing cardiovascular protection.

Purpose of the Study:

  • To determine if daily low-dose aspirin significantly reduces urinary 11-dhTXB₂ in type 2 diabetic patients.
  • To identify clinical and laboratory factors associated with aspirin response in this population.

Main Methods:

  • Eighty-one type 2 diabetic patients were analyzed.
  • Measurements included lipid profile, HbA1c, platelet count, GPIIbIIIa and COX-1 polymorphisms, and urinary 11-dhTXB₂.
  • Urinary 11-dhTXB₂ was assessed before and after 15 days of 100mg daily aspirin.

Main Results:

  • Median urinary 11-dhTXB₂ decreased significantly from 179 to 51 pg/mg creatinine (p=0.00) after aspirin intake.
  • Only 5% of patients showed a substantial (95%) reduction in 11-dhTXB₂.
  • A Body Mass Index (BMI) ≥ 26 was significantly associated with reduced 11-dhTXB₂ levels (p=0.010).

Conclusions:

  • Low-dose aspirin effectiveness in reducing 11-dhTXB₂ shows significant variability in type 2 diabetic patients.
  • Body Mass Index (BMI) is independently associated with aspirin's antiplatelet effect in this cohort.
  • Findings suggest potential for personalized aspirin therapy based on patient characteristics like BMI.
Abstract

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