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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Related Experiment Video

Updated: Jun 2, 2026

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

Layer-by-layer self-assembled shells for drug delivery.

Katsuhiko Ariga1, Yuri M Lvov, Kohsaku Kawakami

  • 1World Premier International Research Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Japan. ARIGA.Katsuhiko@nims.go.jp

Advanced Drug Delivery Reviews
|April 23, 2011
PubMed
Summary
This summary is machine-generated.

Layer-by-layer (LbL) assembly enables the creation of advanced drug delivery systems. This review highlights LbL shells for targeted therapeutic delivery, including encapsulating insoluble drugs and achieving stimuli-free release.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Drug delivery systems require safe and effective methods to avoid side effects from direct injection.
  • Controllable carrier structures are crucial for targeted therapeutic agent delivery.
  • Layer-by-layer (LbL) assembly offers a flexible approach for building functional nanostructures.

Purpose of the Study:

  • To review the preparation of layer-by-layer (LbL) shells for drug delivery applications.
  • To summarize recent advancements in self-assembled microshells and nanoshells for drug delivery.
  • To discuss innovative concepts addressing current challenges in LbL drug delivery.

Main Methods:

  • Fundamentals of layer-by-layer (LbL) assembly are described.
  • Preparation of ultra-thin polyelectrolyte shells on nano-sized drug particles using ultrasonic treatment, polycations, and polyanions.
  • Demonstration of stepwise, stimuli-free drug release from LbL films of mesoporous capsules.

Main Results:

  • LbL assembly provides a method for creating precisely controlled drug delivery carriers.
  • Encapsulation of insoluble drugs within nanoshells is achievable, enhancing practical medical use.
  • Stimuli-free, auto-modulated drug release from mesoporous capsules was successfully demonstrated.

Conclusions:

  • Layer-by-layer assembly is a powerful technique for designing sophisticated drug delivery vehicles.
  • Advanced LbL-based systems offer solutions for targeted delivery and controlled release of therapeutics.
  • Future applications include improved treatment strategies for various medical conditions.