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Updated: Jun 2, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Conventional and novel approaches to immunosuppression
Timothy Floreth1, Sangeeta M Bhorade, Vivek N Ahya
1Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA.
Clinics in Chest Medicine
|April 23, 2011
Summary
Immunosuppressive therapy improves solid organ transplant survival but faces challenges. New agents and monitoring techniques are crucial for overcoming graft rejection and improving long-term outcomes in lung transplantation.
Area of Science:
- Immunology
- Transplantation Medicine
- Pharmacology
Background:
- Immunosuppressive therapy is vital for solid organ transplantation success.
- Chronic graft rejection and treatment adverse events hinder long-term survival, especially after lung transplantation.
Purpose of the Study:
- To review current immunosuppressive regimens for solid organ transplantation.
- To explore novel strategies for preventing graft rejection.
- To discuss investigational agents in transplantation.
Main Methods:
- Review of conventional immunosuppressive strategies.
- Analysis of emerging techniques for immunosuppression monitoring.
- Examination of novel approaches and investigational agents for transplant rejection.
Main Results:
- Current immunosuppression enhances transplant survival but has limitations.
- Graft rejection and adverse events remain significant challenges.
- Advancements in monitoring and new agents show promise.
Conclusions:
- Further improvements in lung transplant outcomes require novel immunosuppressive agents.
- Enhanced understanding of transplant immunobiology is essential.
- Refined monitoring techniques are critical for optimizing immunosuppression.
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