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Updated: Jun 2, 2026
08:33
An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
Extrathyroidal expression of TSH receptor
1Molecular Endocrinology Group, Hammersmith Hospital, London, UK. graham.williams@imperial.ac.uk
Annales D'Endocrinologie
|April 23, 2011
Summary
The TSH receptor is found beyond the thyroid in many tissues, influencing various bodily functions. Research is exploring its extrathyroidal roles and physiological significance, sparking scientific interest.
Area of Science:
- Endocrinology
- Molecular Biology
- Cell Biology
Background:
- The TSH receptor (TSHR) is crucial for thyroid hormone regulation and thyroid gland growth.
- TSHR is increasingly recognized for its expression in numerous extrathyroidal tissues.
Purpose of the Study:
- To review the current understanding of TSHR expression and function in extrathyroidal tissues.
- To discuss the potential physiological implications and ongoing controversies surrounding extrathyroidal TSHR actions.
Main Methods:
- Literature review and synthesis of existing research on TSHR expression and function.
- Analysis of evidence regarding the physiological roles of TSHR in various extrathyroidal sites.
Main Results:
- TSHR is expressed in diverse extrathyroidal tissues, including the pituitary, hypothalamus, reproductive organs, immune cells, adipose tissue, and bone.
- Emerging evidence suggests functional roles for TSHR in these tissues, though their physiological importance is often debated.
Conclusions:
- The widespread extrathyroidal expression of TSHR indicates potential roles beyond thyroid regulation.
- Further research is needed to elucidate the precise physiological functions and clinical relevance of extrathyroidal TSHR.
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