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Updated: Jun 2, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
Published on: September 30, 2025
[Dyslipidemias: a pending challenge in cardiovascular prevention. Consensus document from CEIPC/SEA Committee]
Miguel Ángel Royo Bordonada1, José María Lobos Bejarano, Jesús Millán Núñez-Cortés
1Instituto de Salud Carlos III, Madrid, España. mroyo@isciii.es
Insights
In Spain, hypercholesterolemia is poorly controlled, contributing to high cardiovascular disease (CVD) mortality. A national strategy focusing on lifestyle changes and integrated cardiovascular risk (CVR) management is proposed to improve prevention efforts.
Area of Science:
- Public Health
- Cardiology
- Preventive Medicine
Background:
- Cardiovascular disease (CVD) is the leading cause of death in Spain.
- Hypercholesterolemia is a prevalent, yet poorly controlled, risk factor for CVD in the Spanish adult population.
- Dyslipidemia management requires a comprehensive approach considering overall cardiovascular risk (CVR), not in isolation.
Framework:
- Proposes a national strategy for cardiovascular prevention.
- Emphasizes lifestyle modifications: healthy diet, physical activity, and smoking cessation.
- Integrates CVR assessment into clinical decision-making, acknowledging limitations of calculation methods.
Implementation:
- Population-level interventions: regulate food advertising, eliminate trans fats, reduce added sugars.
- Health-setting interventions: facilitate guideline application, enhance professional training, include CVR assessment in quality indicators.
- Collaboration between scientific societies and health authorities for knowledge generation and dissemination.
Implications:
- Enhancing CVR management can improve dyslipidemia control and reduce overall cardiovascular mortality.
- Multisectoral actions are crucial for effective cardiovascular prevention.
- Healthcare professionals play a key role in promoting healthy lifestyles and optimizing pharmacological treatments.
Abstract:
In Spain, where cardiovascular disease (CVD) is the leading cause of death, hypercholesterolemia, one of the most prevalent risk factors in adults, is poorly controlled. Dyslipidemia should not be approached in isolation, but in the context of overall cardiovascular risk (CVR). Measurement of CVR facilitates decision making, but should not be the only tool nor should it take the place of clinical judgment, given the limitations of the available calculation methods. This document, prepared by the Interdisciplinary Spanish Committee on Cardiovascular Prevention, at the proposal of the Spanish Society of Arteriosclerosis, reviews the cardiovascular prevention activities of the regional health authorities, scientific societies and medical professionals. An initiation of a national strategy on cardiovascular prevention is proposed based on lifestyle modification (healthy diet, physical activity and smoking cessation) through actions in different settings. At the population level, regulation of food advertising, elimination of trans fats and reduction of added sugar are feasible and cost-effective interventions to help control dyslipidemias and reduce CVR. In the health setting, it is proposed to facilitate the application of guidelines, improve training for medical professionals, and include CVR assessment among the quality indicators. Scientific societies should collaborate with the health authorities and contribute to the generation and transmission of knowledge. Finally, it is in the hands of professionals to apply the concept of CVR, promote healthy lifestyles, and make efficient use of available pharmacological treatments.
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