[Hygienic standardization of tin level in the air]

Indices reflecting the functional state of the central nervous system, peripheral blood, enzymes and gonads were used in accordance with the toxico-dynamics of substances. Besides, body mass, behavior of animals, pathomorphological and histochemical indices were studied. 5 concentrations of tin chloride were studied: 400, 80, 15, 3 and 0.5 mg/m3. On the basis of an acute experiment (6-1440 h) it has been established, that the concentration-time relationship according to a number of biochemical and physiological parameters on the graph was expressed by direct lines on the double log scale with angles to abscissa from 124.9 degrees (according to blood transaminase activity reduction) up to 138.2 degrees, which allowed to determine the class of danger, safety and cumulation coefficients, threshold and no-effect concentrations of tin chloride under inhalational exposure to it. The lowest no-effect concentration 0.05 mg/m3 is recommended as an average 24-hour MAC and approved by the USSR Public Health Ministry.