Related Experiment Video
Updated: Jun 2, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
Published on: May 10, 2017
Increased risk of stroke after trigeminal neuralgia--a population-based follow-up study
Shin-Liang Pan1, Li-Sheng Chen, Ming-Fang Yen
1Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung Shan S. Rd, Taipei, Taiwan. panslcb@gmail.com
Background:
There are no reports on the risk of stroke after trigeminal neuralgia (TN). The aim of this population-based follow-up study was to investigate whether the occurrence of TN is associated with a higher risk of developing stroke.
Methods:
A total of 1453 people with at least three ambulatory visits in 2001 with the principal diagnosis of TN were enrolled in the TN cohort. The non-TN cohort consisted of 5812 age- and sex-matched, randomly sampled subjects without TN. The 2-year stroke-free survival rate between the two groups was compared using the Kaplan-Meier method. The Cox proportional hazards regression model was used to estimate the hazard ratio of stroke after adjustment for demographic and clinical covariates.
Results:
In the TN cohort, 73 patients developed stroke during follow-up, while in the non-TN cohort, 157 subjects suffered a stroke. The crude hazard ratio of stroke for the subjects with TN was 1.86 (95% CI, 1.41-2.45; p<0.0001). The adjusted hazard ratio was 1.76 (95% CI, 1.33-2.33; p<0.0001) after adjusting for demographic characteristics and comorbid medical disorders.
Conclusion:
This study showed a significantly increased risk of developing stroke after TN. Further studies are needed to investigate the underlying mechanism of this association.
Related Concept Videos
Hemorrhagic Stroke ll: Pathophysiology
Transient Ischemic Attack l: Introduction
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
Increased Intracranial Pressure ll: Pathophysiology