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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
From polymer to small organic molecules: a tight relationship between radical chemistry and solid-phase organic
Danilo Mirizzi1, Maurizio Pulici
1Department of Chemical Core Technologies, Nerviano Medical Sciences S.r.l., V.le Pasteur, 10, 20014, Nerviano (MI), Italy.
Abstract:
Since Gomberg's discovery of radicals as chemical entities, the interest around them has increased through the years. Nowadays, radical chemistry is used in the synthesis of 75% of all polymers, inevitably establishing a close relationship with Solid-Phase Organic Synthesis. More recently, the interest of organic chemists has shifted towards the application of usual "in-solution" radical chemistry to the solid-phase, ranging from the use of supported reagents for radical reactions, to the development of methodologies for the synthesis of small molecules or potential libraries. The aim of this review is to put in perspective radical chemistry, moving it away from its origin as a synthetic means for solid supports, to becoming a useful tool for the synthesis of small molecules.
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