N-cyanomethylnorboldine: a new aporphine isolated from Alseodaphne perakensis (Lauraceae)
Mohd Azlan Nafiah1, Mat Ropi Mukhtar, Hanita Omar
1Chemistry Department, Faculty of Science and Mathematic, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia. azlan@upsi.edu.my
Abstract:
A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied.
Related Concept Videos
Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview
Aldehydes and Ketones with HCN: Cyanohydrin Formation Mechanism
Physical Properties of Amines
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Nomenclature of Primary Amines
Nomenclature of Aryl and Heterocyclic Amines


