Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Patch Clamp

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A systematic review of risk of HIV transmission through biting or spitting: implications for policy.

HIV medicine·2018

Same author

Prevalence and disease associations in feline thrombocytopenia: a retrospective study of 194 cases.

The Journal of small animal practice·2018

Same author

Using learning outcomes in dental education.

British dental journal·2017

Same author

The dynamics of benzene on Cu(111): a combined helium spin echo and dispersion-corrected DFT study into the diffusion of physisorbed aromatics on metal surfaces.

Faraday discussions·2017

Same author

Probiotics-impregnated bedding covers for house dust mite allergic rhinitis: A pilot randomized clinical trial.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017

Same author

The emergence of enterovirus D68 in England in autumn 2014 and the necessity for reinforcing enterovirus respiratory screening.

Epidemiology and infection·2017

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

iPSC technology: platform for drug discovery. Point.

J Ellis¹, M Bhatia

¹Ontario Human iPS Cell Facility, Toronto, Ontario, Canada. jellis@sickkids.ca

Clinical Pharmacology and Therapeutics

|April 23, 2011

Summary

Induced pluripotent stem cells (iPSCs) offer a powerful new way to test drugs using patient cells. These cells provide advantages over embryonic stem cells (ESCs) for personalized medicine and drug discovery.

Area of Science:

Stem cell biology
Drug discovery and development
Regenerative medicine

Background:

Disease-specific pluripotent stem cells are crucial for understanding affected cell types in drug discovery.
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) enables patient-specific cell generation.
Patient-derived iPSCs allow for studying diverse disease severities and drug metabolism.

Purpose of the Study:

To highlight the advantages of induced pluripotent stem cells (iPSCs) over embryonic stem cells (ESCs) for drug evaluation.
To propose iPSCs as a platform for conducting 'clinical trials on a dish'.

Main Methods:

Generation of patient-specific induced pluripotent stem cells (iPSCs) from somatic cells.
Utilizing iPSCs to create disease-specific cellular models.

More Related Videos

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

Related Experiment Videos

Last Updated: Jun 2, 2026

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Using Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells for Drug Discovery

Published on: May 19, 2018

Comparing the utility of iPSCs versus embryonic stem cells (ESCs) in drug screening.

Main Results:

Induced pluripotent stem cells (iPSCs) provide a viable source of patient-specific cells for disease modeling.
iPSCs enable the study of variable drug metabolism responses across different patients.
Challenges in efficient differentiation and scale-up of iPSCs persist.

Conclusions:

Induced pluripotent stem cells (iPSCs) present significant advantages over embryonic stem cells (ESCs) for drug discovery.
iPSCs facilitate personalized drug testing through 'clinical trials on a dish' models.
Further research is needed to overcome differentiation and scale-up challenges for widespread iPSC application.